C. coclensis
|
Extract |
Leaves (H2O) |
Hypotensive effect on normotensive and hypertensive rats |
40 mg/Kg |
ND |
ND |
Gárcia-González et al. 1998, Gárcia-González et al. 1996 |
C. columnaris
|
Extract |
Stems (CH3OH:CH2Cl2) |
Antimicrobial activity against Enterococcus faecalis (EF) and Pseudomonas aeruginosa (PA) |
ND |
ND |
EF: MIC = 180 μg/mL; MBC = 270 μg/mL PA: MIC = 140 μg/mL; MBC > 200 μg/mL |
Suffredini et al. 2006, Bittar et al.2000 |
I3, II8-Binaringerin (1) |
Leaves (CH3OH) |
Antinociceptive effect in mice |
ND |
IC50 (writhing test)= 22µmol/kg IC50 (formalin test) = 28µmol/kg |
ND |
C. grandiflora
|
Resins |
Staminate flowers |
Antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Candida albicans in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000, Lokvam et al. 2000, Diaz-Carballo et al. 2012 |
Resins |
Pistillate flowers |
Antimicrobial activity against S. aureus and B. subtilis, in bioautography assay |
ND |
ND |
ND |
Nemorosone II (2) |
Trunk latex (C2H5)2O |
Antimicrobial activity against Paenibacillus larvae and P. alvei in bioautography assay |
ND |
ND |
ND |
Chamone I (3) |
Pistillate flower (C2H5)2 O |
7-epi-nemorosone (4) |
Floral resins (C2H5)2O |
Anticancer activity in prostate carcinoma |
ND |
IC50 (LNCaP WT) = 4.12±0.19µM IC50 (LNCaP ETO MDR1+) = 4.81±0.68µM IC50 (PC-3 WT) = 5.01±0.07µM IC50 (PC-3 ETO MDR1+) = 5.1±0.1µM IC50 (DU-145) = 7.3±0.07µM IC50 (DU-145 MDR1+) = 6.8±0.45µM |
ND |
C. guatemalensis
|
Extract |
Leaves (CH3OH:CH2Cl2) |
Inhibition of HIV-1 virus reverse transcriptase |
50 µg/mL |
IC50 (HIV-1 RT) = 42 µg/ml IC50 (HIV-1 IIIb/LAV) = 124.1 µg/ml |
ND |
Huerta-Reyes et al. 2004
|
C. massoniana
|
50 µg/mL |
ND |
C. quadrangula
|
50 µg/mL |
ND |
C. hilariana
|
Extract |
Staminate flowers (CH3OH) |
Antifeedant effect on Rhodnius prolixus larvae, and promotion of ecdise delay. |
100μg/mL |
ND |
ND |
Kelecom et al. 2002
|
Oleanolic acid (5) |
Toxicity on R. prolixus larvae, and promotion of ecdise delay. |
1, 10 e 100μg/mL |
Nemorosone (6) |
Promotion of ecdise delay on R. prolixus larvae |
10μg/mL |
C. insignis
|
Resins |
Staminate flowers |
Antimicrobial activity against S. aureus and B. subtilis in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000
|
C. lanceolata
|
Resins |
Staminate flowers |
Antimicrobial activity against S. aureus, B. subtilis and C. albicans in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000
|
Extract |
Non-galled and galled leaves (CH3OH) |
Antioxidant activity in β-carotene/linoleic acid assay |
57 μg/mL |
ND |
ND |
Ferreira et al. 2014
|
C. nemorosa
|
Resins |
Hermaphrodite flowers |
Antimicrobial activity against S. aureus and B. subtilis in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000
|
Extract |
Leaves (C6H14) |
Anti-inflammatory and antinociceptive effects on male Swiss mice |
62 mg/kg |
IC50 (writhing test) = 62mg/kg |
ND |
Ferro et al. 2013
|
Inhibition of protein exudation, leukocyte influx and TNFα levels on pleurisy induced by carrageenan on male Swiss mice |
100 and 200 mg/kg |
ND |
ND |
Farias et al. 2012
|
Betulinic acid (7) |
Roots (H2O) |
Decrease of body weights, abdominal fat accumulation, blood glucose, plasma triglycerides, and total cholesterol on male Swiss mice |
50 mg/L |
ND |
ND |
Melo et al. 2009
|
C. palmana
|
Extract |
Leaves and flower buds (CH3CH2OH:H2O); Leaves and fruits (CH3CO2C2H5 fraction) |
Neutralization of the hemorrhagic effect induced by Bothrops asper venom in rats |
1:50 (poison / extract ratio) |
ND |
ND |
Castro et al. 1999
|
C. paralicola
|
Clusiparalicoline A (8) |
Roots (CH3CH2OH) |
Scission-promoting activity on DNA strands; cytotoxicity in KB cells; growth promotion of neuritas in fetal cortical neurons of rats. |
neurite outgrowth promoting activity at 1.0 M |
ND |
ND |
Seo et al. 1999, Takaoka et al. 2002
|
Clusiparalicoline B (9) |
Scission-promoting activity on DNA strands; cytotoxicity in the KB cells |
|
|
ND |
|
Clusiparalicoline C (10) |
cytotoxicity in the KB cells |
|
|
ND |
|
Extract |
Unripe fruits (CH3CH2OH) |
Antioxidant activity |
ND |
EC50(DPPH) = 12.7±0.1; EC50(ABTS) = 7.4±0.4; |
ND |
Oliveira et al. 2012
|
C. renggerioides
|
Resins |
Staminate flowers |
Antimicrobial activity against S. aureus and B. subtilis in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000
|
C. rosea
|
Guttiferone E (11) and xanthochymol (12) |
Leaves (CH2Cl2:CH3OH) |
Inhibition of the cytopathic effects of HIV virus in human lymphoblastoid cells |
ND |
1-10 µg/mL |
ND |
Gustafson et al. 1992
|
C. rosea
|
Nemorosone (6) |
Floral resin (CH3CH2OH) |
Cytotoxicity against human cancer cell lines |
ND |
IC50(HELA): 3.3±0.17µM; 1.6±0.08µg/mL IC50(HeP-2): 3.1±0.17µM; 1.5±0.08µg/mL IC50(PC-3): 7.2±1.3µM; 3.6±0.65µg/mL IC50(U251): 3.9±1.4µM; 1.9±0.70µg/mL IC50 (neuroblastoma cells): 3.10±0.15 - 6.3±0.21µM IC50 (MCF-7): 0.03 - 0.1µM |
ND |
Cuesta-Rubio et al. 2002, Díaz-Carballo et al. 2008, Popolo et al. 2011
|
7-epi-nemorosone (4) |
Resins of pistillate flowers |
Antiestrogenic activity |
10, 20 and 40 μg/well |
ND |
ND |
Camargo et al. 2013
|
C. spiritu-sanctensis
|
Nemorosone (6) |
Resins of staminate flowers |
Antimicrobial activity against S. aureus and B. subtilis in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000
|
C. torresii
|
Extracts |
Leaves and flowers (CH3CH2OH:H2O) Leaves and fruits (CH3CO2C2H5 fraction) |
Neutralization of the hemorrhagic effect induced by B. asper venom in rats |
1:50 (poison / extract ratio) |
ND |
ND |
Castro et al. 1999
|
Clusianone (13) |
Fruits (C6H14) |
Inhibition of HIV-1 virus infection in lymphoblastoid T cells (C8166) |
ND |
IC50 = 0.020±0.003 µM |
ND |
Piccinelli et al. 2005
|
|
7-epi-clusianone (14) |
ND |
IC50 = 2.0±0.07 µM |
ND |
C. weddelliana
|
Resins |
Staminate flowers |
Antimicrobial activity against S. aureus and B. subtilis in bioautography assay |
ND |
ND |
ND |
Porto et al. 2000
|
C. fluminensis
|
Extract |
Stems; Leaves; Fruits (H2O) |
Antiophidic |
|
|
|
Da Silva et al. 2019
|
Zeaxanthin (15) |
Fruits (not described) |
Antioxidant and macular degeneration protector. |
|
|
|
Mazza et al. 2019
|
Extract |
Staminate flowers (C6H14) Fruits (C6H14) |
Significant reduction of the survival of the insect Oncopeltus fasciatus |
1.0 mg/mL (1.0µg/ insect) |
ND |
ND |
Duprat et al. 2017
|
Clusianone (13) |
Floral extract (C6H14) |
Reduction on the survival of the insect Dysdercus peruvianus |
0.7 mg/mL (0.7µg/ insect) |
Lanosterol (16) |
Fruit extract (C6H14) |
Significant reduction on both survival and development of the insects O. fasciatus and D. peruvianus |
C. fluminensis
|
Extract |
Leaves (C6H14; CH3OH) |
Inhibitory effect of on proteolysis caused by B. jararaca venom |
venom /extract ratio: 1:5; 1:10; 1:20; and 1:50 |
IC50(hexane): 567μg/mL IC50(methanol): 447μg/mL |
ND |
Oliveira et al. 2014
|
Stems (CH3OH) ((CH3)2CO) |
IC50(methanol): 245μg/mL IC50(acetone): 180μg/mL |
Fruits (C6H14) ((CH3)2CO) |
IC50(n-hexane): 736μg/mL IC50(acetone): 90μg/mL |
Staminate flowers (C6H14; CH2Cl2) |
IC50(n-hexane): 220μg/mL IC50(dichloromethane): 630μg/mL |
Extract |
Staminate flowers (C6H14) |
Significant delay on the development of Aedes aegypti |
50 mg/L |
ND |
ND |
Anholeti et al. 2015a
|
Clusianone (13) |
Staminate flowers (C6H14) |
Significant inhibition of survival and complete blockage of development Ae. aegypti |
C. criuva
|
Extracts |
Leaves (C6H14; CH3OH) |
Antioxidant activity in DPPH assay |
ND |
EC50(n-hexane): 34.66 ± 19.42 g extract/g DPPH EC50(methanol): 12.54 ± 1.43 g extract/g DPPH |
ND |
Da Silva et al. 2017
|
Pericarp (C6H14; CH3OH) |
EC50(n-hexane): 10.94 ± 0.36 g extract/g DPPH EC50(methanol): 5.01 ± 0.16g extract/g DPPH |
Seeds (C6H14; CH3OH) |
EC50(n-hexane): 8.32 ± 0.30g extract/g DPPH EC50(methanol): 4.06 ± 1.12g extract/g DPPH |
C. burlemarxii
|
Extract |
Leaves (CH3CH2OH) |
Antimicrobial activity against B. subtilis and S. aureus |
ND |
ND |
MIC (B. subtilis): 31.25μg/mL MIC (S. aureus): 62.50μg/mL |
Ribeiro et al. 2011
|
|
Trunk (CH3OH) |
Antimicrobial activity against B. subtilis, Streptococcus mutans and Micrococcus luteus |
|
|
MIC (B. subtilis): 62.50μg/mL MIC (S. mutans): 62.50μg/mL MIC (M. luteus): 31.25μg/mL |
|
2,2-dimethyl-3,5-dihydroxy-7-(4-hydroxyphenyl)chromane (17) |
Trunk (CH3OH) |
Antimicrobial activity against B. subtilis, S. aureus, S. mutans and M. luteus |
ND |
ND |
MIC (B. subtilis): 100μg/mL MIC (S. aureus): 50μg/mL MIC (S. mutans): 100μg/mL MIC (M. luteus): 25μg/mL |
|
|
Lyoniresinol (18) |
Leaves (CH3CH2OH) |
Antimicrobial activity against S. aureus |
MIC (S. aureus): 25μg/mL |
|
Rhamnopyranosyl kaempferol (19) |
Antimicrobial activity against B. subtilis and S. aureus |
MIC (B. subtilis): 50μg/mL MIC (S. aureus): 100μg/mL |
C. gundlachii
|
Gundlachiione A (20) |
Fruits (CH3OH) |
Leishmanicidal activity against P. falciparum |
ND |
IC50(promastigote): 11.30μg/mL IC50(amastigote): 0.84μg/mL |
ND |
Zhang et al. 2018
|
Gundlachiione B (21) |
IC50(promastigote): 30.12μg/mL IC50(amastigote): 5.92μg/mL |
Gundlachiione C (22) |
IC50(promastigote): 9.63μg/mL IC50(amastigote): 2.32μg/mL |
C. latipes
|
Extract |
Leaves (C6H14; CH₃CO2C₂H₅; CH3OH) |
Cytotoxic activity against human cancer cell lines (PC-3, RKO, D-384 and MCF-7) |
50μg/ml |
ND |
ND |
Bailón-Moscoso et al. 2016
|
Clusia minor
|
Extract |
Leaves (CH2OH) |
Antinociceptive effect on mice |
150 and 300 mg/kg |
ND |
ND |
Mangas et al. 2019
|
Clusia flava
|
Extract |
Leaves (CH3OH) |
Leishmanicidal activity against P. falciparum |
ND |
IC50(promastigote): 32μg/mL |
ND |
Peraza-Sánchez et al. 2007
|
C. pernanbucensis
|
Extract |
Stem bark (CH₃CO2C₂H₅)) |
Leishmanicidal activity against P. falciparum |
ND |
IC50(amastigote): 65μg/mL |
ND |
Silva et al. 2013
|
Clusiaxanthone (23) |
IC50(amastigote): 66.9μM |
C. amazonica
|
Extract |
Leaves and stems (H2O) |
Leishmanicide |
|
|
|
Odonne et al. 2009
|