Five cases of Sydenham's chorea were treated with Cortisone, Prednisone and/or Prednisolone; Phenobarbital and Chlorpromazine were used as symptomatic and Benzathine-Penicillin as prophylatic medications. Reports of other workers were analyzed and their results compared. It is believed that the following conclusions are justified: 1) hormonal therapy of Sydenham's chorea with ACTH, Cortisone, Prednisone or Prednisolone brings satisfactory results; 2) Prednisone and Prednisolone are the most useful hormones for treatment of Sydenham's chorea, their association with salicylates possibly promising even better results; 3) treatment should be continued until symptoms disappear and the dosage should be individualized according to the severity and progression of the disease; 4) hormonal therapy should be done together with symptomatic (sedatives) and prophylatic (antibiotics) medications.