Cognition in a multiple system atrophy series of cases from Argentina

Cognição em uma série dos casos de atrofia de múltiplos sistemas da Argentina

Cognitive dysfunction may occur in 17-40% of patients with multiple system atrophy (MSA). It has been suggested a milder cognitive impairment in cerebellar (MSA-C) than in parkinsonian variant (MSA-P). However, differences in cognitive profiles remain under discussion.

Objective  To evaluate cognitive features in a series of patients with “probable MSA” from Argentina.

Method  After informed consent was obtained, an extensive cognitive tests battery was administered. Nine patients (6 MSA-P and 3 MSA-C) composed the sample.

Results  Depression was detected in 43% of patients. Seven patients showed at least one cognitive domain impairment. Temporospatial orientation, visuospatial abilities, executive and attentional functions, episodic memory and language were compromised in MSA-P, while MSA-C dysfunction was restricted to attentional and executive domains.

Conclusion  Despite the small sample size, our findings could suggest a more widespread cognitive impairment in MSA-P than MSA-C.

parkinsonism; multiple system atrophy; cognition