Ballard et al. (2016)20 |
IG (GEX): Type: aerobic training (outdoor or exercise bike), resistance training and balance* Duration: 60 min/36 weeks Frequency: once a week Intensity: not specified |
Antipsychotic |
Reduced neuropsychiatric symptoms, except for agitation and depression NPI: T0: IG: 12.02/CG: 15.05; T1: IG: 11.73/CG: 14.89 Effect size: -3.59, p<0.05 CSDD: T0: IG: 4.16/CG: 4.86; T1: IG: 5.15/CG: 5.43 Effect size: -1.21, p=0.43 CMAI: T0: IG: 46.36/CG: 47.91; T1: IG: 46.94/CG: 50.75 Effect size: -1.76, p=0.47 |
CG: social interaction |
Antipsychotic |
Hoffmann et al. (2016)23 |
IG: Type: aerobic exercise: 3×10 min. on ergometer bicycle, cross trainer and treadmill (2–5 min rest between) Duration: 60 min/16 weeks Frequency: three weekly sessions Intensity: moderate to vigorous |
Anti-dementia (acetylcholinesterase inhibitors and/or memantine) Antidepressant |
Reduced neuropsychiatric symptoms, except for depression NPI: T0: IG: 10.0/CG: 9.4; T1: IG: 8.8/CG: 11.4 Effect size: -3.,5, p=0.002 HAM-D: T0: IG: 1.9/CG: 2.0; T1:/IG: 1.7/CG: 1.8 Effect size: -0.1, p=0.791 |
CG: usual care |
Anti-dementia (acetylcholinesterase inhibitors and/or memantine) Antidepressant |
Cancela et al. (2016)22 |
IG: Type: aerobic training (recumbent bicycle) Duration: 15 min/60 weeks Frequency: daily ** Intensity: self-selected |
Anti-dementia (acetylcholinesterase inhibitors and/or memantine) |
Reduced neuropsychiatric symptoms, except for depression NPI: T0: IG: 9.70/CG: 11.32; T1: NA Effect size: NA, p=0.020 CSDD: T0: IG: 6.31/CG: 6.71; T1: NA Effect size: NA |
CG: recreational activities (card games, reading and manual work) |
Anti-dementia (acetylcholinesterase inhibitors and/or memantine) |
Telenius et al. (2015)24 |
IG: Type: resistance training for lower limb muscles (12 MR) and 2 balance exercises Duration: 50 to 60 min/12 weeks Frequency: twice weekly sessions Intensity: vigorous |
NA |
Reduced apathy and agitation, except for depression NPI: T0: IG: 5.8/CG: 4.8; T1: IG: 5.1/CG: 5.4 Effect size: Apathy: 0.3, p=0.048 Agitation: 0.2, p=0.07 CSDD: T0: IG: 4.7/CG: 4.9; T1: IG: 3.8/CG: 3.8 Effect size: 0.2, p=0.39 |
CG: mild physical activity, reading, games, talking, listening to music |
NA |
Öhman et al. (2017)21 |
IG (GE and HE): Type: aerobic training (Nordic walking and bike); resistance training; balance and dual-task exercises (15 min for each modality) Duration: 60 min/52 weeks Frequency: twice weekly sessions Intensity: gradually increased |
1 in 4: Antidepressant 1 in 10: Antipsychotic |
No improvements in neuropsychiatric symptoms NPI: T0: IG: (GE:12.05, HE: 13.45)/CG: 16.56; T1: NA Effect size: not significant/NA, p=0.41 CSDD: T0: IG: (GE:3.9, HE: 4.8)/CG: 5.9; T1: NA Effect size: not significant/NA, p=0.81 |
CG: usual care (physical therapy, if necessary) |
NA |
Lamb et al. (2018)25 |
IG: Type: aerobic training (static cycling) and resistance training (5 exercises for arms and legs) Duration: 60–90-min/16 weeks Frequency: twice weekly sessions Intensity: moderate to vigorous*** |
Anti-dementia (acetylcholinesterase inhibitors and/or memantine) |
No improvements in neuropsychiatric symptoms NPI: T0: IG: 7.5/CG: 10; T1: IG: 12/CG: 9 Effect size: -2.1, p=0.14 |
CG: usual care (physical therapy when necessary) |
Anti-dementia (acetylcholinesterase inhibitors and/or memantine) |
Henskens et al. (2018)19 |
IG (GEX): Type: aerobic training (walk outdoors - 500mts or 1km), resistance training: 13 exercises for upper and lower extremities and the torso: 3 sets of 8 reps Duration: 30-45-min/24 weeks Frequency: three weekly sessions Intensity: gradually increased |
NA |
No improvements in depressive symptoms, apathy and agitation CSDD: T0: IG: 8.3/CG: 8.1; T1: IG: 8.6/CG: 6.7 Effect size: 0.1, p=0.89 CMAI: T0: IG: 51.8/CG: 52.3; T1: IG: 53.4/CG: 52 Effect size: -4.3, p=0.11 AES: T0: IG:23.8/CG: 28.4; T1: IG: 25/CG: 24.8 Effect size: -0.1, p=0.91 |
CG: social interaction (drinking tea)/usual care |
NA |