Resumos
Neoplasias provenientes do epitélio de revestimento do plexo coróide são inco-muns, tendo sido descritos 6 padrões morfológicos. O padrão anaplásico, também denominado carcinoma do plexo coróide, é o de menor freqüência e pode dar metastases fora do SNC. A distinção histológica desses tumores, particularmente da variedade anaplásica, com outras neoplasias primárias e metastáticas no SNC pode ser difícil. O uso de técnicas imunocitoquimicas em parafina tem-se mostrado útil no esclarecimento das linhagens tumorais. Os papilomas do plexo coróide têm, no entanto, sido objeto de controvérsia, por sua complexa expressão antigênica. Usando a técnica de imunoperoxidase (sistema avidina-biotina-peroxidase) pesquisaram-se, em dois casos da variedade anaplásica, os seguintes marcadores: proteína glial fibrilar ácida (GFAP) com anticorpo monoclonal e policlonal; ceratinas de 40-50kDa, ceratinas de 60-70kDa (callus ceratina), enolase neuronal específica (NSE) e proteína S-100, com anticorpos monoclonais. Os dois tumores mostraram positividade para NSE, proteína S-100 e ceratina de 40-50kDa; uma das duas neoplasias mostrou diferenciação glial, revelando positividade para GFAP tanto com anticorpo monoclonal quanto policlonal.
Primary neoplasms of choroid plexus are rare. Six morphological variants have been described: papillary, cystic, acinar, mucus-secreting, oncocytic, and anaplastic. The anaplastic variant, the so-called choroid plexus carcinoma, is the rarest of all and can metastasize. The differential diagnosis of the anaplastic variant of choroid plexus neoplasms with adenocarcinomas, melanomas and indifferentiated neoplasms can be troublesome chiefly in adults. The now large use of immunocytochemical techniques in tissue section has become a powerful tool in the analysis of cell lineages, tumoral and non-tumoral. Nevertheless, the choroid plexus neoplasms have shown a complex and a somewhat confusing pattern of antigenic expression. In two choroid plexus carcinomas (one localized in the right lateral ventricle from a boy of 1 year and 9 months old, and the other localized in the left lateral ventricle from a girl of 3 years old) the following antigens were searched (using the avidin-biotin-peroxydase complex): glial fibrillary acidic protein (GFAP) with monoclonal and polyclonal antibodies; cytokeratins of 40-50kDa, cytokeratins of 60-70kDA (callus cytokeratin), neuronal specific enolase (NSE) and S-100 protein with monoclonal antibodies. The two neoplasms showed immunoreactivity against NSE, S-100 protein and cytokeratin of 40-50kDA The neoplasm of the boy exhibited glial differentiation having immunoreactivity against GFAP with monoclonal and polyclonal antibodies.
M. C. AlmeidaI; C. E. Bacc'hiII; L. S. QueirozIII; N. O. FacureIV
IDepartamento de Medicina Complementar, Universidade de Brasília
IIDepartamento de Patologia, UNESP
IIIDepartamento de Anatomia Patológica
IVDisciplina de Neurocirurgia, UNICAMP
RESUMO
Neoplasias provenientes do epitélio de revestimento do plexo coróide são inco-muns, tendo sido descritos 6 padrões morfológicos. O padrão anaplásico, também denominado carcinoma do plexo coróide, é o de menor freqüência e pode dar metastases fora do SNC. A distinção histológica desses tumores, particularmente da variedade anaplásica, com outras neoplasias primárias e metastáticas no SNC pode ser difícil. O uso de técnicas imunocitoquimicas em parafina tem-se mostrado útil no esclarecimento das linhagens tumorais. Os papilomas do plexo coróide têm, no entanto, sido objeto de controvérsia, por sua complexa expressão antigênica. Usando a técnica de imunoperoxidase (sistema avidina-biotina-peroxidase) pesquisaram-se, em dois casos da variedade anaplásica, os seguintes marcadores: proteína glial fibrilar ácida (GFAP) com anticorpo monoclonal e policlonal; ceratinas de 40-50kDa, ceratinas de 60-70kDa (callus ceratina), enolase neuronal específica (NSE) e proteína S-100, com anticorpos monoclonais. Os dois tumores mostraram positividade para NSE, proteína S-100 e ceratina de 40-50kDa; uma das duas neoplasias mostrou diferenciação glial, revelando positividade para GFAP tanto com anticorpo monoclonal quanto policlonal.
SUMMARY
Primary neoplasms of choroid plexus are rare. Six morphological variants have been described: papillary, cystic, acinar, mucus-secreting, oncocytic, and anaplastic. The anaplastic variant, the so-called choroid plexus carcinoma, is the rarest of all and can metastasize. The differential diagnosis of the anaplastic variant of choroid plexus neoplasms with adenocarcinomas, melanomas and indifferentiated neoplasms can be troublesome chiefly in adults. The now large use of immunocytochemical techniques in tissue section has become a powerful tool in the analysis of cell lineages, tumoral and non-tumoral. Nevertheless, the choroid plexus neoplasms have shown a complex and a somewhat confusing pattern of antigenic expression. In two choroid plexus carcinomas (one localized in the right lateral ventricle from a boy of 1 year and 9 months old, and the other localized in the left lateral ventricle from a girl of 3 years old) the following antigens were searched (using the avidin-biotin-peroxydase complex): glial fibrillary acidic protein (GFAP) with monoclonal and polyclonal antibodies; cytokeratins of 40-50kDa, cytokeratins of 60-70kDA (callus cytokeratin), neuronal specific enolase (NSE) and S-100 protein with monoclonal antibodies. The two neoplasms showed immunoreactivity against NSE, S-100 protein and cytokeratin of 40-50kDA The neoplasm of the boy exhibited glial differentiation having immunoreactivity against GFAP with monoclonal and polyclonal antibodies.
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Dr. Marcos Célio de Almeida - Departamento de Medicina Complementar, Faculdade de Ciências da Saúde. Universidade de Brasília - 70910 Brasília DF - Brasil.
Referências bibliográficas
- 1. DeLellis RA, Dayal Y - The role of immunohistochemistry in the diagnosis of poorly differentiated malignant neoplasms. Semin Oncol 14:173, 1987.
- 2. Doglioni C, Dell' Orto P, Coggi G, Iuzzolino P, Bontempini L, Viale G - Choroid plexus tumors: an immunocitochemical study with particular reference to the coexpression of intermediate filament proteins. Am J Path 127:519, 1987
- 3. Hsu S, Raine L, Fanger H - Use of avidin-biotin peroxidase complex (.ABC) in immunoperoxidase techniques: a comparison between ABC and unabeled antibody (PAP) procedures. J Histochem Cytochem 29:577, 1981.
- 4. Miettinen M, Clark R, Virtanen I - Intermediat filament proteins in choroid plexus and ependyma and their tumors. Am J Path 123:231, 1986.
- 5. Osborn M, Weber K - Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology. Lab Invest 48:372, 1983.
- 6. Perentes E, Rubinstein LJ - Recent applications of immunoperoxidase histochemistry in human neuro-oncology. Arch Path Lab Med 111:796, 1987.
- 7. Rubinstein LJ - Immunohistochemical sign spots not markers in neural tumor differentiation. J Neuropath Appl Neurobiol 12:523, 1986.
- 8. Russell DS, Rubinstein LJ - Pathology of Tumors of the Nervous System. Ed 4. Arnold, London, 1987.
- 9. Zülch KJ - Brain Tumors: Their Biology and Pathology. Ed 3. Springer-Verlag, Berlin, 1986.
Datas de Publicação
-
Publicação nesta coleção
26 Maio 2011 -
Data do Fascículo
Set 1990